Material Compatibility Reference

Hastelloy C-276 — Fluid Compatibility

Which industrial fluids Hastelloy C-276 valves can handle — rated across 15 process media with engineering notes. The compatibility reference for specifying Hastelloy C-276 body and trim.

What fluids is Hastelloy C-276 compatible with?

Hastelloy C-276 is rated across 15 industrial fluids in our compatibility data. It performs well in Acetic Acid (CH₃COOH), Amine (DEA / MEA / MDEA - Gas Sweetening), Caustic Potash (KOH - Potassium Hydroxide), Chlorine (Cl₂), Hydrochloric Acid (HCl), MEG / Glycol (Monoethylene Glycol - Gas Dehydration). Full ratings and notes below — always confirm against concentration, temperature and velocity.

Material grades & metallurgy

ASTM A494 CW6MC / CW12MWHastelloy C-276 / Inconel 625 Cast ASTM B575 / UNS N06022 (Hastelloy C-22)Hastelloy C-22 / Alloy C-22 ASTM B574 / UNS N10276Hastelloy C-276

Excellent11 fluids

Acetic Acid (CH₃COOH)Best choice for glacial and hot acetic acid in PTA oxidation service.

Amine (DEA / MEA / MDEA - Gas Sweetening)Used for hottest, most corrosive amine service points.

Caustic Potash (KOH - Potassium Hydroxide)Excellent across all KOH concentrations and temperatures.

Chlorine (Cl₂)Best all-round choice for both wet and dry service.

Hydrochloric Acid (HCl)Best alloy choice for all concentrations.

MEG / Glycol (Monoethylene Glycol - Gas Dehydration)Used in rich MEG service at elevated temperature in regeneration columns.

Oxygen (O₂ - Industrial and Medical Grade)Used for high-pressure medical oxygen and critical GOX service.

Phosphoric Acid (H₃PO₄)Best choice for wet process phosphoric acid with fluoride impurities.

Sodium Hypochlorite (NaOCl - Bleach)Best metallic choice for concentrated NaOCl.

Sulphuric Acid (H₂SO₄)Excellent across all concentrations. Industry standard for dilute H₂SO₄.

Urea Solution (Carbamide / DEF / AdBlue)Used in the most aggressive urea carbamate conditions in synthesis loops.

Good1 fluids

Chlorine Dioxide (ClO₂)Acceptable for dilute ClO₂ service.

Fair3 fluids

Carbon Monoxide (CO)High nickel content - same Ni(CO)₄ risk as above. Verify with process chemist.

Hydrofluoric Acid (HF)Only for dilute aqueous HF - not for anhydrous or hot concentrated HF.

Nitric Acid (HNO₃)Not ideal for HNO₃ - SS 304L is preferred due to Mo susceptibility.

Reviewed by Materials Engineering, Vajra Industrial SolutionsDiscipline: Valve Metallurgy & Materials SelectionLast reviewed: 20 June 2026

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